Exploring the omnigenic architecture of selected complex traits.

ABSTRACT: Genome-wide association studies (GWASs) have statistically identified thousands of loci influencing a trait of interest. To explain the organizational principles among the functionally often unrelated encoded proteins, the omnigenic model postulates core genes with direct and peripheral genes with indirect effects on molecular trait etiology. However, both core genes and the network paths by which they are influenced are unknown for most traits. Using our previously developed Speos framework to identify core genes, we here focus on the autoimmune disease ulcerative colitis (UC) to explore the regulatory relationships between core and peripheral genes and their organization in multi-modal molecular networks. The identified core genes are characterized by tissue-specific expression and trait

SUBMITTER: Ratajczak F 

PROVIDER: S-EPMC12461020 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature