Comparative Analysis of Primary and Second Primary Multiple Myeloma: A Propensity Score-Matched Study.

ABSTRACT:

Background

With the increasing number of cancer survivors, second primary malignancies (SPMs) are attracting clinical interest. Although SPMs following multiple myeloma (MM) have been studied, data on second primary multiple myeloma (SPMM) remain limited. This study aimed to compare the clinical characteristics and outcomes of SPMM with those of primary MM through a retrospective analysis.

Methods

We retrospectively reviewed 183 patients with primary MM and 12 patients with SPMM treated at a single center between 2003 and 2022. To reduce selection bias, propensity score matching (1:3) was performed based on age, sex, year of MM diagnosis, and International Staging System stage. Survival outcomes were assessed using Kaplan-Meier analysis and Cox proportional hazards models.

SUBMITTER: Jang YJ 

PROVIDER: S-EPMC12461090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature