Taohong Siwu Decoction alleviates high salt-induced calcium overload and ferroptosis in vascular endothelial cells in hypertension by regulating ATF4.

ABSTRACT:

Background

Taohong Siwu Decoction (THSWD), a traditional Chinese medicine formula, is increasingly applied in clinical practice for hypertension management. Our previous research demonstrated that THSWD alleviates high-salt-induced hypertension in mice. This study aims to further elucidate the underlying mechanisms of THSWD in treating hypertension.

Methods

The chemical composition of THSWD was identified using UPLC-Q/TOF-MS in earlier research. In this study, we performed both in vivo and in vitro experiments. ATF4^+/- mice (KO) and C57BL/6 mice (WT) were fed a high-salt diet with or without THSWD treatment. Human aortic endothelial cells (HAECs) were cultured in high-NaCl conditions, with or without ATF4 inhibition. Blood pressure, vascular i

SUBMITTER: Lam LK 

PROVIDER: S-EPMC12461095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature