Network Pharmacology-Based and Experimental Validation Elucidate the Target Mechanism of Vinorine in Ameliorating Secondary Brain Injury After Intracerebral Hemorrhage.

ABSTRACT:

Background

Intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high mortality and long-term disability, for which no effective treatment currently exists. Vinorine (Vin), a monoterpene indole alkaloid derived from Rauvolfia reflexa, has been traditionally used for age-related neurological disorders, yet its therapeutic potential and mechanisms in ICH remain unclear.

Methods

An ICH mouse model was established via intracranial collagenase injection. Vin was administered intraperitoneally at varying doses, and its effects on motor function, sensory deficits, and neural regeneration were evaluated. Network pharmacology was employed to predict potential targets and pathways, followed by validation through molecular docking, in vivo experiments, and in vitro

SUBMITTER: Wu JW 

PROVIDER: S-EPMC12461119 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature