Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.

ABSTRACT:

Background

Congenital hypothyroidism (CH) may lead to irreversible neurological dysfunction of offspring by affecting hippocampal morphogenesis. The dentate gyrus (DG) is primarily the affected tissue by the CH, in which the dendritic spine density of gyrus granule cells (DGCs) is significantly reduced, thereby resulting in the cognitive impairment. The CaMKIV/CREB signaling pathway has been shown to mediate the deficient growth of DGCs dendritic spines, but the mechanism of CH in modulating the Ca²⁺-dependent CaMKIV is still elusive.

Methods

CH model of rat pups was prepared by the supply of 0.02% methimazole in the drinking water of pregnant dams from the 9th day of gestation. The dendritic spine density of hippocampal DGCs was detected by Golgi staining before

SUBMITTER: Li T 

PROVIDER: S-EPMC12461174 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature