Gut microbiome and fecal metabolite profiles in obese school-aged children from Northern Thailand.

ABSTRACT: Although the gut microbiota of school-aged children has been extensively studied, there is a significant lack of knowledge regarding the relationship between fecal metabolite profiles and the gut microbiota in the context of obesity in young children, particularly in Thailand. To elucidate this association, we analyzed fecal gut microbiota and metabolites of 67 school-aged children across various body mass index (BMI) and categorized: normal (n = 30), overweight (n = 20), and obese (n = 17), employing next-generation sequencing (NGS) and ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS), respectively. Obese children exhibited distinct profiles of both gut microbiota and metabolites compared to N and OW

SUBMITTER: Therdtatha P 

PROVIDER: S-EPMC12461226 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature