Antibacterial and wound healing effects of PEG-coated ciprofloxacin-loaded ZIF-8 nanozymes against ciprofloxacin-resistant <i>Pseudomonas aeruginosa</i> taken from burn wounds.

ABSTRACT:

Background

Antimicrobial-resistant (AMR) Pseudomonas aeruginosa (P. aeruginosa) poses a significant challenge in burn wound infections due to its biofilm formation and resistance mechanisms, particularly against ciprofloxacin (CIP). Innovative therapies are urgently needed to improve treatment outcomes for burn patients. This study aimed to develop and evaluate Polyethylene glycol (PEG)-Coated CIP-Loaded zeolitic imidazolate framework-8 (ZIF-8) nanozymes (PEG-ZIF-8-CIP) to enhance antimicrobial efficacy against CIP-resistant P. aeruginosa (CRP) and promote wound healing.

Methods

Clinical isolates of CRP were collected from burn patients and confirmed via polymerase chain reaction for the oprL gene. ZIF-8 nanozymes were synthesized, loaded with CIP

SUBMITTER: Pahlevani M 

PROVIDER: S-EPMC12461262 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature