Aromatic Coupling Reactions Catalyzed by "ene"-Reductase under Visible Light Irradiation.

ABSTRACT: Visible light activates "ene"-reductase to catalyze the cross-coupling reaction between aromatic compounds and diethyl bromomalonate. In this transformation, NADPH and its regeneration system are abandoned, and the cofactor FMN_ox is employed to directly initiate the reaction. This reaction exhibits excellent substrate compatibility, with a maximum catalytic yield of 95%. It expands the range of radical precursors for "ene"-reductase-catalyzed reactions and diversifies the reaction types.

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12461304 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature