Benzoylselenoureas: A Novel Dual-Action Inhibitor Targeting Fungal Growth and Urease Activity in <i>Cryptococcus neoformans</i>.

ABSTRACT: Cryptococcus neoformans cause cryptococcal meningitis, particularly in individuals with compromised immune systems. In this context, urease plays a crucial role in fungal survival by facilitating infection spread and penetration of the blood-brain barrier, making this enzyme a potential target for antifungal therapy. Eleven benzoylselenoureas (BSU) were synthesized in 15-75% yields via a one-pot approach using benzoyl chloride, KSeCN, and anilines containing electron-donating or electron-withdrawing groups. The antifungal and urease inhibitory activities of these compounds were evaluated against C. neoformans. For comparison, the corresponding benzoylthioureas (BTU) analogs were also synthesized to assess the influence of the chalcogen atom on biological activit

SUBMITTER: Costa NEM 

PROVIDER: S-EPMC12461339 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature