Design and Characterization of Langmuir-Blodgett Films Incorporating Europium Complexes and Nucleoside Derivatives for Cancer Therapeutic Applications.

ABSTRACT: The design of multifunctional nanostructured materials with potential for both diagnostic and therapeutic use, the so-called theranostic platforms, is a promising strategy in cancer research. In this study, we report the fabrication and physicochemical characterization of Langmuir and Langmuir-Blodgett (LB) films composed of a triacylated uridine derivative (PNM2), previously described as a prodrug with anticancer potential, and the europium complex Eu-(tta)₃(H₂O)₂, known for its luminescent and structural probe properties. Langmuir monolayers at the air-water interface exhibited high rigidity for PNM2, which was modulated upon incorporation of the europium complex. Surface pressure-area isotherms, surface potential data, and dilatational rheology confirmed

SUBMITTER: Pereira GC 

PROVIDER: S-EPMC12461355 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature