The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.

ABSTRACT:

Introduction

Canine cognitive dysfunction is a valuable model for Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) due to condensed lifespan, naturally occurring clinical signs, genetic diversity, shared environment with humans, and similar molecular and neuropathological hallmarks.

Methods

The objective of the Brain Health Study was to build infrastructure to support a diverse national cohort of companion dogs for in-depth, longitudinal analysis of brain and cognitive health over their lifespan. A complex and well-maintained research platform was critical to facilitate enrollment, retention, and biobanking of biofluids and postmortem tissue.

Results

The research infrastructure is in place for longitudinal data collection, annual biospecimen c

SUBMITTER: McGrath S 

PROVIDER: S-EPMC12461415 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature