Nomogram Based on A-To-I RNA Editing for Predicting Overall Survival in Patients With Breast Cancer.

ABSTRACT: Adenosine-to-inosine RNA editing (ATIRE) is the most common type of RNA editing in higher eukaryotes. Many RNA editing events are associated with the occurrence and development of various tumours. Currently, several ATIRE sites have been used as predictors of cancer prognosis. However, whether some of them can be used as diagnostic and prognostic markers for patients with breast cancer (BRCA) remains unknown. BRCA-related data and RNA editing data were downloaded from the TCGA database, and the patients were randomly divided into training (n = 503) and validation (n = 334) groups. Through univariate Cox regression, Lasso regression, and multivariate Cox regression analysis, nine ATIRE sites related to prognosis in all groups were identified to construct a prognostic model and generate an A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12461418 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature