Isomeric Differences in Nanoparticle's Surface Chemistry Alter Macrophage Interactions In Vitro Due to Protein Corona.

ABSTRACT: The interactions of nanoparticles (NPs) with macrophages after intravenous injection are critical in determining their biodistribution and pharmacokinetics. The formation of protein corona (PC) on the nanoparticles, often a result of NP-plasma protein interactions, influences macrophage response, thereby directly determining the NPs' fate in vivo. While the effect of NPs' surface chemistry on protein corona formation and macrophage interaction is extensively studied, the results are often confounded by the effects of surface charge and hydrophobicity. Therefore, to assess the impact of NPs' surface chemistry alone on protein corona and NP-macrophage interactions, we developed gold (Au) NPs surface-modified with the isomeric amino acids leucine (Leu) and isoleucine (Iso Leu), which h

SUBMITTER: Conjeevaram SB 

PROVIDER: S-EPMC12461424 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature