<i>In Vivo</i> Biostimulatory Efficacy of Ascorbic Acid-Loaded Poly(lactic-<i>co</i>-glycolic Acid) Nanoparticles Hydrogel for Dermal Remodeling.

ABSTRACT: Synthetic, biocompatible, and biodegradable polymers such as poly-l-lactic acid (PLLA) and polycaprolactone (PCL) are used in the form of microparticles (25-200 μm) dispersed in injectable hydrogels for collagen biostimulation through mechanical stimuli and subclinical inflammatory responses. However, their clinical application is limited by adverse effects, including nodule formation and vascular occlusion. As an alternative, nanoparticles based on poly-(lactic-co-glycolic acid) (PLGA), a synthetic, biocompatible, and biodegradable copolymer, loaded with ascorbic acid (AA), a potent antioxidant with pro-collagenic activity, may provide enhanced dermal retention, reduced macrophage recognition, and minimized adverse effects. This study developed AA-loaded PLGA nanoparticles incorpor

SUBMITTER: Colaco ARA 

PROVIDER: S-EPMC12461425 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature