Increased lifelong burden of comorbidities without increased early mortality in hereditary hypophosphatemia: a Danish register study.

ABSTRACT: Hereditary hypophosphatemia (HH) is a rare diseases characterized by excessive renal phosphate wasting. Hereditary hypophosphatemia presents as rickets and osteomalacia in children, and osteomalacia in adults. Previous studies have suggested an increased burden of comorbidities and higher risk of early death in individuals with HH compared with controls. This study investigates the comorbidities in HH throughout life and their association with survival compared with controls. Possible HH cases were initially identified from the Danish National Patient Register (DNPR) using diagnostic codes for rickets or hypophosphatemia between 1971 and 2019, and the diagnosis was verified by the review of medical files. A total of 120 individuals with verified HH (case population) were matched by gender,

SUBMITTER: Beck-Nielsen SS 

PROVIDER: S-EPMC12461693 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature