Sex- and system-specific analysis of blood-based biomarkers and frailty in older adults-the Activity and Function of the Elderly study.

ABSTRACT:

Background

Underlying pathophysiological mechanisms behind frailty are not fully understood.

Objective

To evaluate the sex- and system-specific association of 35 blood-based biomarkers with frailty.

Method

Baseline data from the population-based Activity and Function of the Elderly study (≥65 years), collected between March 2009 and April 2010, was used. Frailty was defined through a frailty index (FI). Biomarkers associations with frailty were analysed sex-, and organ-/system-specific. Frailty models were built using backwards selection in Generalized Linear Models (GLM) for continuous and logistic regression (LR) for dichotomized FI (FI ≥0·2 frail), adjusting for age, education, smoking and alcohol intake, with further adjustment for medications when needed. Residua

SUBMITTER: Boehm FJ 

PROVIDER: S-EPMC12461695 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature