Manganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: <i>in vivo</i> study.

ABSTRACT:

Introduction

Magnetic Resonance Imaging (MRI)-guided photothermal therapy (PTT) holds significant promise for the treatment of solid tumors, however, its diagnostic and therapeutic efficacy in malignant pleural mesothelioma (MPM) remains underexplored. To address the limitations of traditional gadolinium (Gd)-based MRI contrast agents, such as intolerance in patients with renal insufficiency and T1 signal attenuation at high field strengths, as well as oxidative stress damage caused by manganese ion leakage from manganese-based materials, this study aims to develop highly chelated and stable manganese polydopamine (Mn-PDA) multifunctional nanoprobes for MRI monitoring and PTT treatment of MPM.

Methods

Mn²⁺ and dopamine were chelated into Mn-PDA NP nanospheres in a

SUBMITTER: Lei L 

PROVIDER: S-EPMC12461733 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature