Changes in the Prevalence of Antimalarial Partner Drug Resistance Markers and Policy in 6 Sub-Saharan African Countries From 2000 to 2021: A Systematic Review.

ABSTRACT:

Background

Prompt malaria case management is a cornerstone for malaria control and elimination. However, this strategy is threatened by the development of antimalarial drug resistance. Resistance is mediated through spontaneous genetic changes such as mutations, but drug pressure is the main driver of resistance spread. Molecular markers of resistance may provide insight into spatiotemporal dynamics of drug resistance and how drug policy changes may affect the spread of resistance.

Methods

We conducted a systematic review to assess the dynamics of Pfcrt, Pfmdr1, Pfdhfr, and Pfdhps mutations from 2000 to 2021. Six countries from sub-Saharan Africa were selected by availability of molecular data and varying antimalarial drug policies: Kenya, Malawi,

SUBMITTER: Walker A 

PROVIDER: S-EPMC12461838 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature