Comprehensive analysis of aging-related genes and immune infiltration landscape in ischemic cardiomyopathy.

ABSTRACT:

Background

Ischemic cardiomyopathy (ICM), which arises from obstructive coronary artery diseases, is a leading cause of heart failure. Aging is a major risk factor for cardiovascular diseases, yet its connection to ICM remains unclear. This study aimed to investigate the role of aging-related gene expression in the context of ICM.

Methods

Human microarray data (GSE116250) were retrieved from the GEO database and aging-related differentially expressed genes (ARDEGs) were identified using the Aging Atlas database. Functional enrichment and protein-protein interaction (PPI) network analyses were performed to elucidate the functions and interactions of these ARDEGs, leading to the identification of hub genes. The immune infiltration landscape in ICM was further characterized. Su

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12461871 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature