Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.

ABSTRACT: Osteoarthritis of the knee (KOA) is a degenerative disease characterized by the deterioration, destruction, and proliferation of articular cartilage and synovium. Autophagy, a crucial intracellular homeostatic mechanism, significantly contributes to the pathogenesis of OA. Platelet-rich plasma (PRP), derived from autologous blood, contains a high concentration of platelets that secrete various growth factors, promoting the regeneration and repair of joint structures. In this experiment, we compared leukocyte-rich platelet-rich plasma (LR-PRP) with leukocyte-poor platelet-rich plasma (LP-PRP) in a rabbit osteoarthritis model induced by papain to investigate the therapeutic efficacy and mechanism of action of platelet-rich plasma on osteoarthritis. Additionally, we analyzed whether different

SUBMITTER: Sun L 

PROVIDER: S-EPMC12461960 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature