Correlation between the mutation rates for ampC derepression and species or ampC genotypes in Enterobacter cloacae complex.

ABSTRACT:

Background

In this study, we investigated the correlation between the mutation rates for ampC derepression and species or ampC genotypes in Enterobacter cloacae complex (ECC) susceptible to ceftriaxone. Non-duplicate ceftriaxone-sensitive ECC isolates (90) were obtained from September 2021 to January 2023 at Ruijin Hospital, Shanghai. hsp60 genotyping and PCR were used for species and ampC identification, respectively. Thirteen strains with the negative ampC amplification results were sequenced, and the mutation rates for ampC derepression were determined by performing Luria-Delbrück fluctuation analyses.

Results

Among these isolates, E. hormaechei was the most prevalent (54.44%), followed by E. roggenkampii (12.22%), E. cloacae (11.11%), E. bugandensis (10.00%), E. asburiae

SUBMITTER: Xie L 

PROVIDER: S-EPMC12461982 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature