Timely Intervention in Light Chain Cardiac Amyloidosis.

ABSTRACT:

Background

Light-chain cardiac amyloidosis (AL-CA) is often overlooked and misdiagnosed as simple diastolic dysfunction, which can lead to worse outcomes if an accurate diagnosis is delayed.

Case summary

This case highlights the importance of utilizing a multidisciplinary team approach and multimodality imaging, such as cardiac magnetic resonance and endomyocardial biopsy, in the prompt diagnosis and treatment of AL-CA with a tailored hematologic treatment regimen in a 70-year-old male. Patient achieved complete remission with Dara-CyBorD (daratumumab, cyclophosphamide, bortezomib, and dexamethasone) therapy in 5 months, demonstrating stabilization and potential reversal of myocardial dysfunction.

Discussion

Of the many causes of heart failure with preserved ejection

SUBMITTER: Rahman A 

PROVIDER: S-EPMC12462088 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature