Mitral Annular Calcification: Natural History, Prognosis, and Clinical Outcomes.

ABSTRACT:

Background

Mitral annular calcification (MAC) is a chronic and progressive degenerative process characterized by calcium and lipid deposition of the mitral valve annulus. We sought to describe the natural history of patients with MAC with and without mitral valve dysfunction (MVD).

Methods

We conducted an observational study of patients with an echocardiogram-based diagnosis of MAC from 2006-2023. Patients were matched by age and sex in a 1:1 ratio to patients without MAC. We collected baseline clinical, echocardiographic, and computed tomography data. The primary end point was all-cause mortality. We also report predictors of mortality in patients with MAC and MVD.

Results

We included 15,372 patients in the analysis: 7686 with MAC (median age, 76 years [68-84], 58% w

SUBMITTER: Mendez-Hirata G 

PROVIDER: S-EPMC12462118 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature