CCDC137 knockdown suppresses bladder cancer progression by downregulating SCD.

ABSTRACT:

Background

The Coiled-coil domain-containing (CCDC) family, due to its unique protein structural domain and broad involvement in diverse biological processes, has emerged as a focus in oncology research. Nevertheless, its clinical significance and function in bladder cancer (BLCA) remain poorly defined.

Methods

Machine learning algorithms were employed to identify pivotal CCDC genes in the cancer genome atlas (TCGA), and a prognostic model was subsequently constructed. Multi-omics data encompassing pan-cancer cohorts, single-cell sequencing, and spatial transcriptomics were integrated to characterize the expression patterns and prognostic significance of Coiled-coil domain-containing 137 (CCDC137), a previously uncharacterized CCDC family member in BLCA. Tissue microarray co

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12462137 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature