Molecular pathogenesis of <i>Haemophilus ducreyi</i> infection in human volunteers.

ABSTRACT: SUMMARYHaemophilus ducreyi is a Gram-negative coccobacillus that forms a distinct lineage with Aggregatibacter pleuropneumoniae and Mannheimia haemolytica within the Pasteurellaceae. H. ducreyi causes chancroid, which is characterized by painful genital ulcers (GU) and inguinal lymphadenitis, and facilitates the transmission of HIV. Although once thought to be exclusively sexually transmitted, H. ducreyi is now recognized as a major cause of non-sexually transmitted cutaneous ulcers (CU) on the lower legs of children who live in yaws-endemic areas. Due to the impact of chancroid on global health, the lack of human specimens, and the need to understand H. ducreyi pathogenesis, in 1993, we developed a model in which healthy adult volunteers are infec

SUBMITTER: Spinola SM 

PROVIDER: S-EPMC12462288 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature