Association of social isolation, loneliness and risk of cardiovascular diseases: Meta-analysis of cohort studies.

ABSTRACT:

Background

The association between social isolation, loneliness and risk of cardiovascular diseases (CVD) is not fully understood. This meta-analysis aims to explore social isolation and loneliness whether increases the risk of CVD.

Methods

Data sources was PubMed and Embase from inception to 10 February 2025. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). Hazard ratios (HR) with 95% confidence intervals (CI) were pooled using a random-effect model, and publication bias was assessed with funnel plots and Egger's test.

Results

This meta-analysis included six cohort studies with a total of 5,253,128 participants, spanning a follow-up period of 4 to 11.3 years from publications between 1996 and 2022. All studies were of high qual

SUBMITTER: Wang L 

PROVIDER: S-EPMC12462301 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature