A novel strategy for nephritis-associated infections: dual-antibacterial/anti-inflammatory effects of Schiff base.

ABSTRACT: To address the antimicrobial treatment needs for lupus nephritis and pyelonephritis, this study designed and synthesized ten Schiff base derivatives using 4-(diethylamino)salicylaldehyde as the core scaffold via aldehyde-amine condensation reactions. Activity screening identified compound D5 as exhibiting potent antibacterial activity against Staphylococcus aureus ATCC 29213 with an MIC of 8 μg mL^-1, demonstrating low cytotoxicity toward mammalian cells (HK-2, LO2) and no hemolysis at 256 μg mL^-1. Mechanistic studies revealed that D5 disrupts bacterial membrane integrity, causing leakage of intracellular proteins and DNA. Furthermore, it completely eradicated bacteria within 10 hours at 8 × MIC concentration with a low propensity for resistance induction

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12462367 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature