MVSO-PPIS: a structured objective learning model for protein-protein interaction sites prediction via multi-view graph information integration.

ABSTRACT:

Motivation

Predicting protein-protein interaction (PPI) sites is essential for advancing our understanding of protein interactions, as accurate predictions can significantly reduce experimental costs and time. While considerable progress has been made in identifying binding sites at the level of individual amino acid residues, the prediction accuracy for residue subsequences at transitional boundaries-such as those represented by patterns like singular structures (mutation characteristics of contiguous interacting-residue segments) or edge structures (boundary transitions between interacting/non-interacting residue segments) still requires improvement.

Results

we propose a novel PPI site prediction method named MVSO-PPIS. This method integrates two complementary feature extr

SUBMITTER: Wang S 

PROVIDER: S-EPMC12462378 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature