Rationally designed sonocatalyst-enhanced supramolecular ferroptosis inducers for effective cancer therapy.

ABSTRACT: Ferroptosis is a promising strategy against apoptosis-resistant tumors, yet traditional iron-induced approaches face safety issues and unsatisfied efficacy within complex tumor microenvironments, highlighting the need for biocompatible and highly effective ferroptosis inducers. Herein, we rationally constructed a series of supramolecular ferroptosis inducers (Ru1-Ru3) with sonosensitivity and sonocatalytic properties via molecular engineering, designed for cancer treatment through near-infrared fluorescence-guided sonodynamic therapy. Among them, Ru3 exhibited high ultrasound-triggered ¹O₂ generation efficiency (Φ _Δ = 0.89) owing to its extended π-conjugated system and enhanced intramolecular charge transfer effect. Moreover, Ru3 possesses cat

SUBMITTER: Pang Y 

PROVIDER: S-EPMC12462429 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature