Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.

ABSTRACT:

Background

The polymyxin antibiotic colistin is used as a final line of treatment for life threatening infections caused by multidrug resistant and carbapenem-resistant Gram-negative bacteria. Mobile colistin resistance genes mcr-9 and mcr-10 are increasingly detected in Enterobacteriaceae but their epidemiology is poorly understood.

Methods

The genetic characteristics of mcr-9 and mcr-10, being the only mobile colistin resistance genes detected in a local population of Enterobacter species isolated from bloodstream infections in Dartmouth Hitchcock Medical Center, USA, were elucidated and contextualized against a global dataset of mcr-9/10-bearing plasmids using genomic and phylogenetic tools.

Results

Seven out of 59 Enterobacter isolates carry either an mcr-9 or mcr

SUBMITTER: Ikhimiukor OO 

PROVIDER: S-EPMC12462442 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature