Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.

ABSTRACT:

Background

Obstructive sleep apnea (OSA), and other sleep disorders, are associated with increased risk of developing diabetes mellitus (DM). We examined whether sleep disorders influence the genetic risk of developing diabetes in Hispanic/Latino individuals.

Methods

We developed Type 2 Diabetes (T2D) polygenic risk score (T2D-PRS) useful in admixed Hispanic/Latino individuals. We estimated the association of the T2D-PRS with cross-sectional (n = 12,342) and incident (n = 6965) DM in the Hispanic Community Health Study/Study of Latinos (ages 18-76, 50.9% female). We conducted a mediation analysis with T2D-PRS as an exposure, incident DM as an outcome, and OSA as a mediator. Additionally, we performed Mendelian randomization (MR) analysis to assess the causal relationship bet

SUBMITTER: Hrytsenko Y 

PROVIDER: S-EPMC12462445 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature