Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells.

ABSTRACT: Arterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it is appreciated that defective formation or compromised function of arteries is associated with a range of human diseases, the cellular and molecular mechanisms mediating arterial development remain little understood for most organs. Here, we show with genetic approaches that a small subpopulation of endothelial cells inside the intestinal villi of the embryonic mouse, characterized by the expression of endothelial cell-specific molecule 1 (Esm1/endocan), gives rise to arterial endothelium in the intestinal wall but also in the distant mesenteric vasculature. This involves cell migration but also substantial changes in morphology and gene expression. Immunohisto

SUBMITTER: Bovay E 

PROVIDER: S-EPMC12462501 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature