Development of Diagnostic Nomograms Using Corneal Nerve Parameters for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus.

ABSTRACT:

Purpose

Diabetic peripheral neuropathy (DPN), a common complication of type 2 diabetes mellitus (T2DM), lacks effective diagnostic tools. This study aimed to develop a nomogram that integrates corneal nerve parameters for individualized DPN risk prediction.

Methods

A total of 111 patients with T2DM and 110 healthy controls were enrolled. All participants underwent bilateral corneal confocal microscopy (CCM). High-quality images were selected by four blinded investigators. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), and corneal nerve fiber density (CNFD) were quantified using ACCMetrics and AiCCMetrics software. Diagnostic models-including single- and multi-parameter models-and a nomogram incorporating CNFL, CNBD, CNFD, and age were developed. Mode

SUBMITTER: Qiao Q 

PROVIDER: S-EPMC12462533 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature