DrugCombo: an informatics bridge for anticancer drug combination Phase I trial design.

ABSTRACT: The promise of combinational drug therapies for cancer is hindered by the high failure rate of Phase I trials, perhaps attributable to the inavailability of an integrated source of toxicity data for cancer drugs to aid clinicians and biostatisticians designing trials. To this end, we developed DrugCombo, a knowledge base that integrates drug toxicity along with other data for single drugs and drug combinations from various sources. We extracted drug toxicity data from drug labels using the Microsoft Research Bidirectional Encoder Representations from Transformers for Biomedical Text Mining (MSR BiomedBERT) and manually from PubMed. DrugCombo is the first such database to contain crucial data, such as maximum tolerable dose (MTD), dose-limiting toxicity (DLT), and dose range, for Phase I cl

SUBMITTER: Wang L 

PROVIDER: S-EPMC12462634 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature