<i>ROPN1</i> Gene Expression as a Prognostic and Predictive Biomarker in Aggressive Breast Cancer: Clinical Implications and Survival Association.

ABSTRACT:

Objective

The ropporin-1 (ROPN1) gene, initially linked to sperm motility, is differentially expressed in triple negative breast cancer (TNBC), suggesting a role in tumor progression and therapy resistance. To characterize ROPN1 expression in breast cancer and evaluate its association with clinicopathological features, survival, and treatment response as a translational biomarker.

Materials and methods

Data from The Cancer Genome Atlas (1,087 patients), Sweden Cancerome Analysis Network-Breast (3,273 patients), and geodatabases were analyzed. ROPN1 transcriptional levels were assessed in relation to clinical variables and survival. Chemotherapy agents and epigenetic modulators were tested in cell lines to evaluate ROPN1 regulation.

Resul

SUBMITTER: Cintra RC 

PROVIDER: S-EPMC12462725 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature