Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High-Resolution Black-Blood MRI.

ABSTRACT:

Background

Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge.

Purpose

To investigate changes of cerebral small vessels in CADASIL using iso-0.5 mm black-blood MRI.

Study type

Case control study.

Population

Thirty-six genetically confirmed CADASIL patients (23 female, 43 ± 12.48 years) and 35 matched healthy controls (27 female, 40 ± 11.57 years).

Field strength/sequence

3T using a T1-weighted turbo spin-echo with variable flip angles sequence.

Assessment

Vessel density images (VDIs) were derived from black-blood MRI by using a semi-automatic pipeline with a Jerman filter. The differences in VDI were assessed between CADASIL and con

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12462767 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature