Metabolomics-based identification and validation of the creatine precursor guanidinoacetic acid for frailty in older adults.

ABSTRACT:

Background

Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabolite patterns associated with frailty and validate the most significant metabolite for identifying and predicting frailty in cross-sectional and longitudinal analyses.

Methods

The "Fujian Prospective Aging Cohort" (ChiCTR 2000032949) enrolled 2,265 community-dwelling individuals aged 60 and above in 2020. Plasma metabolites were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Frailty was assessed using Fried's phenotype and the Frailty Index.

Results

Widely targeted metabolomic analysis identified 889 metab

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12462772 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature