Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation.

ABSTRACT: Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system. Non-toxigenic Bacteroides fragilis, a common human colon symbiote, has been shown to alleviate colitis. However, the underlying mechanisms of this alleviation remain incompletely understood. Herein, it is demonstrated that promoting the secretion of B. fragilis outer membrane vesicles (Bf^OMVs+) enhances its ability to alleviate dextran sodium sulfate (DSS)-induced colitis, while inhibiting B. fragilis OMV secretion (Bf^OMVs-) reduces this effect. Bf^OMVs+ alleviates colitis by inhibiting neutrophil recruitment and neutrophil extracellular trap (NET) formation. Further, B. fragilis OMVs (Bf-OMVs) are

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12462929 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature