Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair.

ABSTRACT: Osteoarthritis (OA) is a typical degenerative disease characterized primarily by the degeneration of cartilage. However, current treatments for cartilage degeneration often lead to the formation of hypertrophic cartilage and fibrocartilage, making it challenging to achieve full-thickness cartilage. Here, dual-modular hydrogel microparticles (dmHMPs) are developed, which enable precise spatio-temporal modulation and dynamic equilibrium between immune responses and cartilage regeneration. dmHMPs can modulate the inflammatory microenvironment of the joint by promoting the polarization of synovial macrophages toward an anti-inflammatory phenotype. Consequently, as inflammation is mitigated, synovium-derived mesenchymal stem cells recruited by dmHMPs can efficiently undergo chondrogenic differe

SUBMITTER: Chen X 

PROVIDER: S-EPMC12462947 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature