Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications.

ABSTRACT: Livestock farming and conventional meat production pose significant environmental, health, and animal welfare challenges. In seeking sustainable alternative solutions, cultivated meat technology typically utilizes differentiation of myogenic progenitor cells (MPCs) into muscle cells for in vitro meat production. However, understanding the molecular determinants governing MPC differentiation into muscle cells, and the potential enhancement of this process through modulation of signaling pathways, remains limited. Herein, we characterized the molecular landscape associated with bovine MPC differentiation in vitro by employing multiomics, and explored its augmentation by small molecules, together leading to identification of media that enhanced myogenic differentiation compared with conventio

SUBMITTER: Trautmann CL 

PROVIDER: S-EPMC12462954 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature