Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury.

ABSTRACT: Cancer patients have a higher risk of all types of cardiovascular diseases (CVDs). Cardiologists are encountering a growing number of cancer patients with CVDs, and an increasing number of cancer patients undergoing percutaneous coronary intervention (PCI). The mechanistic link between cancer and CVDs remains elusive. Here, the meta-analysis shows the increased incidence ratio of all-cause mortality and cardiovascular (CV) mortality in patients undergoing PCI with cancer compared with non-cancer. We experimentally demonstrated that cancer aggravated mitochondrial dysfunction and myocardial ischemia/reperfusion (I/R) injury in two models of lung cancer in mice. Plasma extracellular vesicles (EVs) derived from cancer mice exacerbated cardiac I/R injury in vivo and in vitro, while inhibition

SUBMITTER: Mei Z 

PROVIDER: S-EPMC12462958 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature