Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment.

ABSTRACT: Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV-irradiated keratinocytes. To safely exploit this mechanism, extracellular vesicles are isolated from UV-irradiated keratinocytes, designate ^UVKEV, and assess their potential as immunomodulatory agents in the mouse model of inflammatory bowel disease (I

SUBMITTER: Liu L 

PROVIDER: S-EPMC12462966 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature