A Mitochondria-Targeted Nanozyme Platform for Multi-Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation.

ABSTRACT: Transition metal-based nanotherapeutics, such as chemodynamic therapy and ferroptosis- or cuproptosis-induced strategies, hold great potential for cancer treatment. Copper- and iron-based nanozymes enhance reactive oxygen species (ROS) generation and regulate metal ion homeostasis, driving ferroptosis and cuproptosis. However, simultaneous delivery of copper and iron ions and the role of mitochondria-targeted copper in inducing cuproptosis remain underexplored. Here, a dual-functional nano-heterojunction platform, MIL-Cu_1.8S-TPP/FA, is reproted, integrating iron- and copper-based components for synergistic ferroptosis and cuproptosis induction. Mitochondria-targeted Cu_1.8S nanodots demonstrated high biocompatibility and efficiently induced cuproptosis by disrupting mi

SUBMITTER: Liu C 

PROVIDER: S-EPMC12462976 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature