Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome.

ABSTRACT: Red mark syndrome (RMS) is a disease affecting rainbow trout. Although the precise etiology of this disease is still under debate, a Midichloria-like organism (MLO) is suspected as the triggering agent. RMS provokes characteristic skin lesions. Previous investigations pointed to a local immune response characterized by a B cell influx. To elaborate on these findings, here, this study extensively characterizes systemic and local B cell responses in RMS-affected fish. The local influx of IgM+ B cells to the skin lesions is confirmed, and a differentiation of these B cells to plasma-like cells is demonstrated. IgM repertoires suggested a polyclonal activation of local B cells and some trafficking between skin and head kidney. Finally, the fact that transcripts of the gene coding for MLO 16S r

SUBMITTER: Herranz-Jusdado JG 

PROVIDER: S-EPMC12462978 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature