A Promising Point-of-Care Testing Strategy: Ultrasmooth Gold Nanogroove Arrays Biosensor Combined with Initial Rate Analysis.

ABSTRACT: Nowadays, plasmonic biosensors have achieved the limit of detection (LOD) far beyond the clinical or professional standards in the sensing field through material and structural optimizations. However, it remains predominantly a research tool due to the challenge to simultaneously achieve mass production, ultrasensitive and rapid detection, high-reproducibility, and ease of integration, which are extremely desired in point-of-care testing (POCT)-based commercial products. Here, a label-free, ultrasensitive, and rapid assay protocol is described for quantitative protein detections in serum samples, which integrates an ultrasmooth gold nanogroove arrays (UGNA) biosensor with an initial rate analysis (IRA) method. i) Compared with the existing plasmonic biosensors, miscellaneous-protein-mixed

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12462996 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature