Nanoscale Metal-Organic Framework-Based Self-Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy-Radiodynamic Therapy.

ABSTRACT: Radiotherapy-radiodynamic therapy (RT-RDT) has emerged as a promising approach due to its remarkable anticancer efficacy. However, hypoxic tumor microenvironment and insufficient energy deposition severely reduce the radiotherapy outcomes. Herein, lonidamine (LND)-loaded Fe(III) metal-Pt(II) porphyrin framework (FPTM-LP) is designed for radiosensitization through hypoxia alleviation and reactive oxygen species (ROS) amplification. Specifically, the high-Z element Pt effectively absorbs X-ray photons to generate •OH for RT while transferring X-ray energy to porphyrin (TCPP), which stimulates the generation of ¹O₂ for RDT. Moreover, by the inhibition of oxidative phosphorylation, the weak acidity and glutathione (GSH)-responsive release of LND achieves O₂ eco

SUBMITTER: Du S 

PROVIDER: S-EPMC12463018 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature