CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression.

ABSTRACT: Endothelial dysfunction and abnormal activation of the monocyte-macrophage system form a critical loop in atherosclerosis. The role of migrasomes in endothelial-immune interactions remains unclear. This study explores migrasome evolution in the atherosclerotic (AS) microenvironment, highlighting their function as amplifiers in the inflammatory cascade. Through analysis of ApoE^-/- mouse models and single-cell multi-omics data, migrasome activity is mapped using Gene Set Variation Analysis (GSVA) algorithms. Co-culture systems and anti-Cluster of differentiation 74 (CD74) blocking experiments are employed to investigate immune-metabolic reprogramming triggered by migrasome cargo signaling. Advanced imaging and functional studies demonstrated that the interaction between amyloid pr

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12463019 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature