Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis.

ABSTRACT: Temporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function. Therapeutic strategies for TMJOA designed to maintain cartilage homeostasis remain largely unknown. Here, it is reported that orosomucoid 1 (ORM1) attenuated TMJOA progression by maintaining cartilage homeostasis. It is demonstrated that ORM1 is down-regulated in the synovial fluid of patients with TMJOA and condylar cartilage of unilateral anterior crossbite (UAC) rats. Administration of ORM1 protein significantly inhibited cartilage matrix degradation and alleviated TMJOA progression in UAC rats. At the mechanistic level, ORM1 binds to vimentin

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12463022 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature