Engineered Probiotic-Powered Micro-Rod Robot Bomb for Thrombus-Penetrating Explosion.

ABSTRACT: Conventional thrombolytic agents demonstrated limited efficacy in treating thrombotic disorders characterized by narrow therapeutic windows and progressive vascular injury, lacking the required precision, timeliness, and treatment durability. Here an engineered probiotic powered micro-rod robot for targeted and penetrative treatment for thrombus is developed. This micro-rod robot (_SrEcN_PL) using natural probiotics as bio-carriers, functionalized with thrombolytic carbon nanotubes and platelet membrane-coated nanoparticles loaded with targeted vasodilators. The robot exploits the rapid movement of probiotics, combined with the active targeting ability of the platelet membrane, to achieve rapid and precise drug delivery to thrombus tissue. Based on the natural rod-shape

SUBMITTER: Liu R 

PROVIDER: S-EPMC12463029 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature