Interfacial Roughness-Reinforced Magnetic Nanosheet Colloidal Gels for Stable Embolization and Magnetothermal Therapy of Hepatic Tumor.

ABSTRACT: Injectable hydrogels have been developed for transcatheter arterial embolization (TAE) of hepatic tumor owing to their flexibility in injection and embolization. However, the dual requirement for high mechanical robustness and good injectability poses a fundamental challenge, as improvements in one often compromise the other. Colloidal gels offer tunable mechanical properties and feasible injectability through the bottom-up assembly of building blocks. Here an interfacial reinforcement strategy is developed by enhancing specific surface area and roughness to fabricate nanosheet-mica (NM) magnetic colloidal gels (NMMG). The negatively charged NM, exfoliated from natural ground mica (GM), possessed increased binding sites, while in situ grown Fe₃O₄ nanoparticles enhance

SUBMITTER: Liu X 

PROVIDER: S-EPMC12463041 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature